• Immunodysregulation
• Inborn Errors of Immunity
• Autoimmune Disorders
• Mastocytosis and Mast Cell Disorders
• Food Allergy
• Atopic Dermatitis

Fellowships

• University of California, Davis, 1993, Allergy & Immunology

Residency

• Children's Hospital of Los Angeles, 1989, Pediatrics

Internships

• Children's Hospital of Los Angeles, 1987, Pediatrics

Medical Education

• Georgetown University, 1989
• Georgetown University School of Medicine, 1985

Certifications

• American Board of Allergy and Immunology-Allergy & Immunology
• American Board of Pediatrics-Pediatrics

Publications

Recent Publications

• Chang C. Immunodysregulation in immunodeficiency. Allergy Asthma Proc. 2024 Sep 1;45(5):340-346 doi: 10.2500/aap.2024.45.240058. PMID 39294914
• Zhu P, Wang X, Wu Q, Zhu J, Que Y, Wang Y, Ding Y, Yang Y, Jin J, Zhang X, Xu Q, Yong Q, Chang C, Xu G, Du Y. BCAP31 Alleviates Lipopolysaccharide-Mediated Acute Lung Injury via Induction of PINK1/Parkin in Alveolar Epithelial Type II Cell. Research (Wash D C) 2024 Oct 8:7:0498. doi: 10.34133/research.0498. eCollection 2024. PMID 39381793
• Yang B, Chen Y, Jiang J, Chang C, Wu H, Gershwin ME, Lu Q. The importance of developing reproducible primary endpoints for clinical trials in systemic lupus erythematosus. Clin Rheumatol. 2025. Jan; 44(1): 193-192. doi: 10.1007/s10067-024-07236-4. PMID 39579266
• Xin Y, Yang M, Zhao Z, He Z, Mei Y, Xiong F, Tan F, Chen A, Chang C, Dai H, Wu H, Lu Q. AIM2 deficiency in CD4+ T cells promotes psoriasis-like inflammation by regulating Th17-Treg axis via AIM2-IKZF2 pathway. J Autoimmunity. 2025, 150; https://doi.org/10.1016/j.jaut.2024.103351 PMID 39689661
• Davis CM, Akin C, Bahna SL, Hsu-Blatman KS, Carr T, Chang C, Chong HJ, Ciaccio CE, Davis BP, Fadugba O, Fuleihan RL, Grayson MH, Gupta S, Hemler JA, Kuma R, Mahdavinia M, Miller RL, Nelson MR, Nowak-Wegrzyn AH, Poowuttiful P, Tripople JW, Vickery BP, Zheng T. The state of the academic medical center in allergy/immunology: Work Group Report of the AAAAI A/I Division Directors Committee. J. Allergy Clin Immunol. 2025, PMID 40742349
• Borges S, Pereira VA, Chang C,, Galor A. Where eye meets body part 1: uniting allergy pathways in ocular and nasal disease – IgE on the offence. Curr Opin Allergy Clin Immunol. 2025 Oct 1;25(5):355-363. doi: 10.1097/ACI.0000000000001096. Epub 2025 Aug 1. PMID 40747986
• Borges S, Pereira VA, Chang C, Galor A. Where eye meets body part 2: uniting allergy pathways in ocular and atopic disease – T cells take the lead. Curr Opin Allergy Clin Immunol. 2025 Oct 1;25(5):364-373. doi: 10.1097/ACI.0000000000001097. Epub 2025 Aug 1. PMID 40747966
• Maharaj S, Chang C. Can juvenile idiopathic arthritis be cured. Curr Opin Immunol. 2025 Oct: 96:102632 doi: 10.1016/j.coi.2025.102632. Epub 2025 Aug 11. PMID 40795628
• Zhao W, Gao L, Chang C, Hana M, Satnarine T, Brozyna J, Sun J, Xi G, Wong GWK. AAAAI/WAO 2025 meeting update: Climate change, asthma, artificial intelligence, food allergy and immunotherapy. Allergy Medicine (2025) 6, https://doi.org/10.1016/j.allmed.2025.100074.

       Recent Book Chapters

• Zhou S, Wu H, Chang C, Lu Q. Unproven and controversial testing methods in allergy and immunology. In Allergic and Immunologic Diseases. 1st edition. Chang C (eds). Elsevier. London, 2022; Chapter 24: 687-724
• Wiers-Shamir K, Simpson J, Chang C. The evaluation and treatment of autoimmune diseases. In Allergic and Immunologic Diseases. 1st edition. Chang C (ed). Elsevier. London, 2022; Chapter 32: 863-886
• Rodriguez Y, Restrepo L, Chang C, Anaya, JM. Neurologic autoimmune diseases. In Allergic and Immunologic Diseases. 1st edition. Chang C (eds). Elsevier. London, 2022; Chapter 33: 887-978
• Ramirez L, Shenderov F, Chang C. Drug desensitization. In Allergic and Immunologic Diseases. 1st edition. Chang C (eds). Elsevier. London, 2022; Chapter 35: 1005-1038
• Hamburger N, Chang C. Endometriosis as an Autoimmune Diseases. In The Rose and Mackay Textbook of Autoimmune Diseases, eds. Gershwin ME, Tsokos G, Diamond B, Mackay C. Elsevier 2024 
• Telatin M, Chang C. Managing Autoimmune Diseases through Personalized Epigenetic Approaches. In Personalized Epigenetics, eds Tollefsbol T. Elsevier 2024, pp 601-627
• Li Q, Lei Y, Zhang P, Lui Y, Lu Q, Chang C. Future Challenges and Prospects for Personalized Epigenetics. In Personalized Epigenetics, eds Tollefsbol T. Elsevier 2024, pp 721-744
• Rodriguez Y, Chang C, Gonzalez-Bravo DC, Gershwin ME, Anaya JM. Guillain-Barre Syndrome. In Neuroimmune Diseases: From Cells to the Living Brain. Eds. Mitoma H, Manto M. Springer Cham 2024, 1-29

       Books

• Chang CC, Incaudo GA, Gershwin ME, eds. Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment. Second Edition. New York. Springer, 2014
• Lu Q, Chang C, Richardson, B, eds. Epigenetics and Dermatology. Amsterdam, Elsevier, 2015
• Chang C, Lu Q. Epigenetics in Allergy and Autoimmunity. Advances in Experimental Medicine and Biology series. New York, Springer, 2020
• Chang C. Allergic and Immunologic Diseases. A practical guide to the evaluation, diagnosis and management of allergic and immunologic diseases. Elsevier, London, October 14, 2022 (e-book), Nov 11, 2022 (published in 2-volume set)
• Chang C. The Cytokines (in progress)

Research

My research interests include, but are not limited to, immune regulatory disorders, inborn errors of immunity, food allergies, autoinflammatory disease, mastocytosis and mast cell diseases, neonatal lupus and epigenetics, which is the study of changes in gene expression.

Below is a small sampling of my research projects:

• Seafood Allergy research, UCDMC
• Principal Investigator for LAAST/MICT asthma study
• Strive JIA registry
• Food allergy research, Nemours bioresearch
• Principal Investigator for atopic dermatitis research, Nemours Bioresearch
• Principal Investigator for immunoglobulin research study, Nemours Bioresearch
• Principal Investigator for immunodeficiency in CF patients, Nemours Bioresearch
• Principal Investigator for mold allergy research, Nemours Bioresearch
• Principal Investigator for Pacific Rim allergy trial in collaboration with the University of Hong Kong
• Principal Investigator for UC Davis seafood allergy trial Principal Investigator for UC Davis mold allergy trial
• Principal Investigator for Pacific Coast Allergy Medical Corp (see below)
• Research on Kawasaki Disease in Hong Kong with Dr. Y.L. Lau, Department of Paediatrics, University of Hong Kong
• Allergy research on skin-prick testing and in-vitro allergen specific IgE with Dr. Georges Halpern, visiting Professor, Department of Pathology, University of Hong Kong

Presentations

• October 29th, 2025: Carrier Connection, West Palm Beach, FL
• October 9th, 2025: IDF, Washington, DC
• August 8th, 2025: Immune dysregulation, Allergy/Immunology fellows joint boot camp, Pembroke Pines, FL
• August 8th, 2025: Mastocytosis and mast cell activation syndrome, Allergy/Immunology fellows joint boot camp, Pembroke Pines, FL
• August 2nd, 2025: Artificial Intelligence in Allergy and Immunology, Florida Allergy, Asthma and Immunology Society (FAAIS) annual meeting, Orlando, FL
• August 1st, 2025: Urticaria, Florida Allergy, Asthma and Immunology Society (FAAIS) annual meeting, Orlando, FL
• July 19th, 2025: Artificial Intelligence in Allergy and Immunology, Tennessee Society of Allergy, Asthma and Immunology (TSAAI) annual meeting, Pigeon Forge, TN
• June 28th, 2025: Toll-like Receptors, 8th Annual Meeting of the Chinese Allergy Society Hangzhou, PRC
• February 25th, 2016: Asthma and Allergic rhinitis TEVA sponsored conference, Napa, CA
• March 30th, 2016: Asthma and Allergic rhinitis TEVA sponsored conference, Santa Rosa, CA
• April 7th, 2016: Session moderator The pathogenesis and etiology of autoimmunity 10th International Congress of Autoimmunity, Leipzig, Germany
• April 8th, 2016: The Zika virus and autoimmunity: GBS as a case in point 10th International Congress of Autoimmunity, Leipzig, Germany
• May 24th, 2016: Asthma and Allergic rhinitis TEVA sponsored conference, Sausalito, CA
• August 2nd, 2016: Asthma and Allergic rhinitis TEVA sponsored conference, Napa, CA
• October 11th, 2016: Anaphylaxis Second Xiangya Hospital, Central South University, Changsha, China
• December 5st, 2016: Asthma and Allergic rhinitis TEVA sponsored conference, Ukiah, CA
• July 22nd, 2015: Basic immunology North Bay Allergy and Asthma, Napa, CA
• August 4th, 2015: Food allergy North Bay Allergy and Asthma, Napa, CA
• October 22, 2015: How to write a scientific paper Second Xiangya Hospital, Central South University, Changsha, China

Awards

• President, Broward County Medical Association, 2026
• Board of Regents, American College of Allergy, Asthma and Immunology, 2025
• Physician Leadership Academy, Broward County Medical Association, 2023
• Excellence award, Program Director, Allergy and Immunology, MHS, 2022
• Leadership Institute, AAAAI, 2015 & 2016
• Dean’s Certificate, Temple University Fox School of Business, 2014
• Beta Gamma Sigma, Temple University Chapter, 2014
• Golden Key International Honors Society, 2014
• University of California at Davis, AAAAI Volunteer Faculty Award for 15 years of service, 2008
• University of California at Davis, AAAAI Volunteer Faculty Award for 25 years of service, 2018